文献类型：期刊文献

英文题名：Three-Dimensional Printing of Calcium Carbonate/Hydroxyapatite Scaffolds at Low Temperature for Bone Tissue Engineering

作者：Wang, Tiandi[1];Zheng, Jianchao[2];Hu, Tianzhou[1];Zhang, Hongbo[1];Fu, Kun[2];Yin, Ruixue[1];Zhang, Wenjun[3,4]

机构：[1]East China Univ Sci & Technol ECUST, Complex & Intelligent Res Ctr, Shanghai, Peoples R China;[2]Hainan Hosp, Haikou, Hainan, Peoples R China;[3]Shanghai Univ, Sch Mechatron & Automat, Shanghai, Peoples R China;[4]Univ Saskatchewan, Coll Engn, Saskatoon, SK, Canada

年份：2021

卷号：8

期号：1

起止页码：1

外文期刊名：3D PRINTING AND ADDITIVE MANUFACTURING

收录：;EI(收录号：20210809973365);WOS:【SCI-EXPANDED(收录号:WOS:000619498500001)】；

语种：英文

外文关键词：bone tissue engineering; 3D printing; hydrothermal process; CaCO3; HA

摘要：Three-dimensional (3D) printing technology has been applied to fabricate bone tissue engineering scaffolds for a wide range of materials with precisely control over scaffold structures. Coral is a potential bone repair and bone replacement material. Due to the natural source limitation of coral, we developed a fabrication protocol for 3D printing of calcium carbonate (CaCO3) nanoparticles for coral replacement in the application of bone tissue engineering. Up to 80% of CaCO3 nanoparticles can be printed with high resolution using poly-l-lactide as a blender. The scaffolds were subjected to a controlled hydrothermal process for incomplete conversion of carbonate to phosphate to produce CaCO3 scaffold covered by hydroxyapatite (HA) to modify the biocompatibility and degradation of CaCO3/HA scaffolds. X-ray diffraction and Fourier transform infrared spectroscopy showed that HA was converted and attached to the surface of the scaffold, and the surface morphology and microstructure were studied using a scanning electron microscope. To confirm the bone regeneration performance of the scaffold, cell proliferation and osteogenic differentiation of MC3T3 cells on the scaffold were evaluated. In addition, in vivo experiments showed that CaCO3/HA scaffolds can promote bone growth and repairing process and has high potential in bone tissue engineering. ClinicalTrials.gov ID: SH9H-2020-A603