文献类型：期刊文献

英文题名：Colorimetric Chiral Recognition of Enantiomers Using the Nucleotide-Capped Silver Nanoparticles

作者：Zhang, Min[1];Ye, Bang-Ce[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Lab Biosyst & Microanal, Shanghai 200237, Peoples R China

年份：2011

卷号：83

期号：5

起止页码：1504

外文期刊名：ANALYTICAL CHEMISTRY

收录：;EI(收录号：20111013719544);WOS:【SCI-EXPANDED(收录号:WOS:000287685800004)】；

基金：This work was financially supported by NSF21075040, the Shanghai 09JC1404100, NCET-07-0287, SKLBE Fund 2060204, and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Amino acids - Nucleotides - Colorimetry - Metal nanoparticles - Enantiomers

摘要：Chiral recognition is among the important and special modes of molecular recognition. It is highly desirable to develop a simple, rapid, sensitive, and high-throughput routine assay for chiral recognition. In this study, we demonstrate that nucleotide-capped Ag nanoparticles (AgNPs) can be used as an ultrahigh efficiency enantioseparation and detection platform for D-and L-cysteine. The aggregation of AgNPs is selectively induced by an enantiomer of cysteine, which allowed the rapid colorimetric enantiodiscrimination of cysteine without any prior derivatization and specific instruments and left an excess of the other enantiomer in the solution, thus resulting in enantioseparation. This is the first application of a nucleotide-capped AgNP-based biosensing platform for chiral recognition and opens new opportunities for design of more novel enantiosensing strategies and enantiospecific adsorbents and expansion of its application in different fields.