文献类型：期刊文献

英文题名：An Efficient Synthesis of (+)- Subersic Acid

作者：Wang, Jing[1];Wang, Peiqiang[1];Li, Jue[1];Wu, Peiying[3];Ren, Jiangmeng[1];Zeng, Bubing[1,2]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China;[3]Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China

年份：2015

卷号：33

期号：6

起止页码：679

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000356425200012)，CCR-EXPANDED(收录号:WOS:000356425200012)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21302053), Science and Technology Commission of Shanghai Municipality (No. 14DZ1900102) and the Fundamental Research Funds for the Central University (No. WY1113007).

语种：英文

外文关键词：(+)-subersic acid; (-)-Sclareol; cross coupling; Heck reaction

摘要：This paper describes a concise and practical route to (+)-subersic acid from naturally occurring (-)-Sclareol in 7 steps. The key step of this route relied on the cross coupling of the diterpene with the arene fragment using the arylation of allylic acetate followed by beta-acetoxy elimination type Heck reaction.