文献类型：会议论文

英文题名：Controllable fabrication of porous PLGA/PCL bilayer membrane for GTR using supercritical carbon dioxide foaming

作者：Song, Chaobo[1];Li, Shuang[2];Zhang, Jiapeng[1];Xi, Zhenhao[1];Lu, Eryi[2];Zhao, Ling[1];Cen, Lian[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Stomatol, Shanghai 200127, Peoples R China

会议论文集：9th International Conference on Advanced Nano Materials (ANM)

会议日期：JUL 19-21, 2017

会议地点：Univ Aveiro, Aveiro, PORTUGAL

主办单位：Univ Aveiro

语种：英文

外文关键词：GTR; Bilayer membrane; Supercritical foaming; PLGA; PCL

摘要：In present study, an efficient solvent-free foaming method aided by supercritical carbon dioxide (sc-CO2) is developed to prepare porous PLGA/PCL bilayer membranes for potential guided tissue regeneration (GTR) applications. First rheological properties and foaming behaviors of PLGA and PCL were studied in detail. Compared with PLGA, PCL had lower viscosity with loss tangent tan delta over 1 thus got bigger and highly interconnected pores after foaming. Based on this, membranes with distinct porous PCL and PLGA bilayer were prepared via a one-step foaming. SEM showed the pore size of the PCL layer was 80-100 mu m, and that of the PLGA layer was less than 10 mu m. Through tensile tests these membranes exhibited a tensile strength of 4.02 MPa and a elongation at break of 57.7 %, meeting the mechanical requirements of GTR. Further cell tests demonstrated that the PCL layer suited for the proliferation of osteoblasts and the PLGA layer inhibited the ingrowth of fibroblasts. The porous PLGA/PCL bilayer membranes fabricated using this one-step foaming meet the requirements of GTR and possess great commercial potential. (C) 2018 Elsevier B.V. All rights reserved.