文献类型：专利

英文题名：Levo-lactone hydrolase producing fungus and its method for preparing chiral hydroxyacid

作者：XU J;ZHANG X;PAN J;XU Y;CHEN B;PAN H

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY;[2]UNIV EAST CHINA SCI&TECHNOLOGY;[3]UNIV EAST CHINA SCI&TECHNOLOGY

申请号：CN101535467-A

公开日：2009-09-16

语种：英文

收录：DERWENT

摘要：NOVELTY - The invention relates to levorotation lactone specificity hydrolytic enzyme producing strain and its use to make chiral oxyacid. The enzyme producing is Fusarium proliferatum NirenbergECU2002 with storage number CGMCC 1494. The chiral oxyacid preparing method includes: (1) using the fungus mycelium, rough enzyme extract or their immobilization derivative as biocatalyst; (2) processing antipode selectivity hydrolysis resolution for a series of racemic chirality lactone to gain many optically active (+)-oxyacid and (+)-lactone which can be hydrolyzed into (-)-oxyacid; (+)-alpha-hydroxyl-beta, beta-dimethyl-gamma-butyric acid which are D-(+)-pantoic acid; and (3) simple acidizing to gain chirality intermediate D-(-)-pantoic acid lactone widely used in preparing feed and daily chemical engineering industry.