文献类型：期刊文献

中文题名：用GC-FID和GC-TOF-MS方法分析α-硫辛酸中有机溶剂残留量

英文题名：Determination of residual solvents in α-lipoic acid by GC-FID and GC-TOF-MS

作者：胡慧廉[1];丁乃立[1];吴莲珍[1]

机构：[1]华东理工大学分析测试中心,上海200237

年份：2006

卷号：25

期号：7

起止页码：102

中文期刊名：分析试验室

外文期刊名：Chinese Journal of Analysis Laboratory

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：气相色谱法;色-质联用;残留有机溶剂;α-硫辛酸

外文关键词：Gas chromatography; GC-MS; Residual organic solvents; α-lipoic acid

摘要：采用GC-TOF-MS鉴定残留有机溶剂，以HP-5毛细管柱为分离柱，FID为检测器，正辛醇为溶剂，外标法进行定量。乙醚、异丙醚的线性范围分别为34．4～344．0μg／mL（r=0．9999），23．0～230．0μg／mL（r=0．9999）；方法精密度和稳定性试验RSD（n=6）均〈1％；平均回收率范围98．1％～100．7％，RSD0．75～2．7％；检出限分别为0．1，0．08μg／mL。
A method for the determination of residual organic solvents in α-lipoic acid has been developed by gas chromatography. There were two kinds of residual solvents in α-lipoic acid identified by GC-TOF-MS. The analysis was performed on HP-5 capillary column with 1-octanol as solvent. The external standard method was used for quantitative analysis. The standard curves were linear in the range of 34.4 - 344.0 μg/mL （ r = 0.9999） for diethyl ether and 23.0 - 230.0 μg/mL （ r = 0.9999） for di-iso-propyl ether. The relative standard deviations （ n = 6） of precision and stability were less than 1%. The average recoveries for both residual solvents were between 98.1% and 100.7% with RSD in the range of 0.75 % - 2.7 %. The detection limits were 0.1μg/mL for diethyl ether and 0.08 μg/mL for di- iso-propyl ether.