文献类型：期刊文献

英文题名：Structure Engineering of a Lanthanide-Based Metal-Organic Framework for the Regulation of Dynamic Ranges and Sensitivities for Pheochromocytoma Diagnosis

作者：Hao, Ji-Na[1];Niu, Dechao[1];Gu, Jinlou[1];Lin, Shaoliang[1];Li, Yongsheng[1];Shi, Jianlin[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Frontier Sci Ctr Mat Biol & Dynam Chem,Sch Mat Sc, Lab Low Dimens Mat Chem,Key Lab Ultrafine Mat,Min, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2020

卷号：32

期号：23

外文期刊名：ADVANCED MATERIALS

收录：;EI(收录号：20201908613267);WOS:【SCI-EXPANDED(收录号:WOS:000528810200001)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2018YFC1105702), the National Natural Science Foundation of China (Nos. 51621002, 21805087, 51873061, and 51972112), Shanghai Sailing Program (18YF1405900), China Postdoctoral Science Foundation (2017M621383), Program of Shanghai Academic/Technology Research Leader (18XD1401400), Basic Research Program of Shanghai (17JC1404702, 19JC1411700), Leading Talents in Shanghai in 2018, and the 111 project (B14018).

语种：英文

外文关键词：metal-organic frameworks; pheochromocytoma diagnosis; tailorable structures; tunable biosensors; vanillylmandelic acid

摘要：Exploring innovative technologies to precisely quantify biomolecules is crucial but remains a great challenge for disease diagnosis. Unfortunately, the humoral concentrations of most biotargets generally vary within rather limited scopes between normal and pathological states, while most literature-reported biosensors can detect large spans of targets concentrations, but are less sensitive to small concentration changes, which consequently make them mostly unsatisfactory or even unreliable in distinguishing positives from negatives. Herein, a novel strategy of precisely quantifying the small concentration changes of a certain biotarget by editing the dynamic ranges and sensitivities of a lanthanide-based metal-organic framework (Eu-ZnMOF) biosensor is reported. By elaborately tailoring the biosensor's structure and surface areas, the tunable Eu-ZnMOF is developed with remarkably enhanced response slope within the "optimized useful detection window," enabling it to serve as a powerful signal amplifier (87.2-fold increase) for discriminating the small concentration variation of urinary vanillylmandelic acid (an early pathological signature of pheochromocytoma) within only three times between healthy and diseased subjects. This study provides a facile approach to edit the biosensors' performances through structure engineering, and exhibits promising perspectives for future clinical application in the non-invasive and accurate diagnosis of severe diseases.