文献类型：期刊文献

英文题名：Small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes

作者：Zhu, Jun-Long[1];Xu, Zheng[2];Yang, Yangyang[3];Xu, Lin[1,4]

机构：[1]East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 3663 N Zhongshan Rd, Shanghai, Peoples R China;[2]Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Clayton, Vic, Australia;[3]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai, Peoples R China;[4]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

年份：2019

卷号：55

期号：47

起止页码：6629

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000471062800001)】；

基金：Thanks to all excellent authors whose names appear in the references. We acknowledge the financial support of the National Natural Science Foundation of China (No. 21871092 and 21672070), Shanghai Pujiang Program (18PJD015), and the State Key Laboratory of Fine Chemicals (KF 1801).

语种：英文

摘要：In the past few years, the preparation of novel small-molecule fluorescent probes for specific detection and imaging of chemical species inside lysosomes has attracted considerable attention because of their wide applications in chemistry, biology, and medical science. This feature article summarizes the recent advances in the design and preparation of small-molecule fluorescent probes for specific detection of chemical species inside lysosomes. In addition, their properties and applications for the detection and imaging of pH, H2O2, HOCl, O-2(center dot), lipid peroxidation, H2S, HSO3, thiols, NO, ONOO, HNO, Zn2+, Cu2+, enzymes, etc. in lysosomes are discussed as well.