文献类型：专著

英文题名：Efficient Biocatalytic Synthesis of Chiral Chemicals

作者：Zhang, Zhi-Jun[1];Pan, Jiang[1];Ma, Bao-Di[1];Xu, Jian-He[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Lab Biocatalysis & Synthet Biotechnol, 130 Meilong Rd, Shanghai 200237, Peoples R China

出版社：SPRINGER-VERLAG BERLIN

出版日期：20160101

出版地：HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY

页数：52

纸书定价：0

isbn号：978-3-662-49161-4; 978-3-662-49159-1

语种：英文

外文关键词：Biocatalysis; Data mining; Efficient biocatalytic synthesis; Chiral chemicals; High volumetric productivity

摘要：Chiral chemicals are a group of important chiral synthons for the synthesis of a series of pharmaceuticals, agrochemicals, and fine chemicals. In past decades, a number of biocatalytic approaches have been developed for the green and effective synthesis of various chiral chemicals. However, the practical application of these biocatalytic processes is still hindered by the lack of highly efficient and robust biocatalysts, which usually results in the low volumetric productivity and high cost of the bioprocesses. Further step forward of biocatalysis in industrial application strongly requires the development of versatile and highly efficient biocatalysts, aiming to increase the process efficiency and facilitate the downstream processing. Recently, the fast growth of genome sequences in the database in post-genomic era offers great opportunities for accessing numerous biocatalysts with practical application potential, and the so-called genome mining approach provides time-effective and highly specific strategy for the fast identification of target enzymes with desired properties and outperforms the traditional screening of soil samples for microbial enzyme producers of interest. A number of biocatalytic processes with industrial application potential were developed thereafter. Further development of protein engineering strategies, process optimization, and cooperative work between biologists, organic chemists, and engineers is expected to make biocatalysis technology the first choice approach for the eco-friendly,highly efficient, and cost-effective synthesis of chiral chemicals in the near future.