文献类型：期刊文献

英文题名：An acidic medium-compatible deep-near-infrared dye for in vivo imaging

作者：Dong, Yan[1];Zou, Ye[1];Jia, Xiaotong[1];Yin, Lei[1];He, Weiwei[1];Luo, Xiao[1];Qian, Xuhong[1];Yang, Youjun[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China

年份：2023

卷号：1

期号：1

外文期刊名：SMART MOLECULES

收录：WOS:【ESCI(收录号:WOS:001498801800001)】；

基金：This work was supported by the National Key Research and Development Program of China (No. 2022YFD17800), the National Natural Science Foundation of China (Nos. 22078098, and 22278138), the Shanghai Academic Technology Research Leader (22XD1421000), the Research Funds of Happiness Flower ECNU (2020JK2103), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

外文关键词：acidic medium; gastrointestinal tract; In vivo imaging; near infrared fluorophore

摘要：In vivo imaging in the deep near-infrared (NIR) spectral region, that is, beyond 800 nm, has become popular due to its penetration depth. While imaging of the neutral medium/tissue has been repeatedly showcased, imaging of the high-acidic medium remains challenging partly because of the high-lying HOMO orbital and hence a high pKa of the electron-donating group of the NIR fluorophores. We devised a novel electron-donating group (D6) with which we further synthesized ECJ. ECJ exhibits an absorption wavelength beyond 900 nm and is fluorescent. Its pKa was found to be lower than zero, rendering it suitable for bioimaging of a highly-acidic medium. Its potential for practical applications was showcased in proof-of-concept in vivo imaging with a mouse model.