文献类型：期刊文献

英文题名：Sequential H2S-Triggered Redox Relay Nanoprobes for Self-Sustained Chem-Illuminating Cascade Photodynamic Therapy

作者：Yang, Jing[1,2];Lu, Yao[1,2];Zhang, Yutao[1,2];Zhao, Xiuyan[1,2];Li, Xie[3];Yan, Chenxu[1,2];Zhao, Yuzheng[3];Zhu, Wei-Hong[1,2];Guo, Zhiqian[1,2,3]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr,Sch Ch, Frontiers Sci Ctr Materiobiol & Dynam Chem,Shangha, Inst Fine Chem,Joint Int res Lab Precis Chem & Mol, Shanghai, Peoples R China;[3]E China Univ Sci & Technol, Synthet Biol & Biotechnol Lab, State Key Lab Bioreactor Engn, Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai, Peoples R China

年份：2026

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20262821064209);Scopus(收录号：2-s2.0-105043961169);WOS:【SCI-EXPANDED(收录号:WOS:001812824300001)】；

基金：This work was supported by National Key Research and Development Program (2023YFA1802000), NSFC/China (22225805, 22308101, 32394001, 22378126, T2488302, and 32121005), Shanghai Science and Technology Innovation Action Plan (no. 23J21901600), and Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China (JYB2025XDXM404).

语种：英文

外文关键词：activatable; chemiluminescent probe; hydrogen sulfide; nanophotosensitizer; photodynamic therapy

摘要：Endogenous chemiluminescence offers a transformative approach to photodynamic therapy that circumvents the limited penetration of external light and enables tumor-selective activation. However, most chemiluminescence-driven photodynamic therapy (CL-PDT) systems typically rely on intracellular oxidants (e.g., H2O2) as chemiexcitation "fuels", which conceptually contradicts the primary goal of elevating intratumoral oxidative stress. In this study, we report a sequential H2S-triggered redox relay nano-photosensitizer, NP-Rubine, which addresses the fundamental "redox paradox" by decoupling photon generation from oxidation consumption. Composed of an H2S-responsive chemiluminescent probe (Rubine) and a N-oxide scaffold (OPDEA-Ppa), NP-Rubine is selectively activated by endogenous H2S to initiate an efficiency chemiluminescence resonance energy transfer (CRET) cascade for efficient singlet oxygen (1O2) production. Concurrently, the N-oxide moiety promotes deep tumor penetration via transcytosis and depletes the intracellular NADPH pool. By synergistically coupling oxidant generation with reductant exhaustion, NP-Rubine synergistically amplifies intracellular redox imbalance to induce apoptosis. In vivo studies substantiate that NP-Rubine achieves exceptional deep-tissue imaging and potent antitumor efficacy in HCT116 xenografts. This bio-reductant, self-sustained targeted CL-PDT strategy circumvents the practical hurdles of oxidation-fueled systems, offering a robust benchmark for precision nanomedicine in complex redox landscapes.