文献类型：期刊文献

英文题名：Identification and Mechanistic Studies of a Cell Cycle Regulator JP18 from a Library of Synthetic Indole Terpenoid Mimics

作者：Pei, Jinpeng[1];Zhou, Shupeng[2];Yang, Fan[1];Sun, Yu[2];Li, Ang[2];Zhang, Wei-Dong[1,3];He, Weiwei[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Collaborat Innovat Ctr Chem Life Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China;[3]Second Mil Med Univ, Dept Phytochem, Sch Pharm, 325 Guohe Rd, Shanghai 200433, Peoples R China

年份：2016

卷号：11

期号：19

起止页码：2715

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20163202682287);WOS:【SCI-EXPANDED(收录号:WOS:000387464000019)】；

基金：We thank Prof. Xuhong Qian for his kind support. Financial support was provided by Ministry of Science & Technology (2013CB836900), Chang Jiang Scholars Program, National Natural Science Foundation of China (21525209, 21290180, 21572064, 81230090, 81520108030, and 81502956), Chinese Academy of Sciences (XDB20020000), Shanghai Science and Technology Commission (15JC1400400 and 15PJ1401300), and Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300).

语种：英文

外文关键词：CDK/cyclin complexes; cell cycle arrest; hybrid structures; indoles; terpenoids

摘要：We constructed a small library of indole terpenoid mimics using a hybridizing strategy to link various indole and alpha,beta-unsaturated enone building blocks together. Prepared compounds were evaluated for the cytotoxicity against a panel of cancer cell lines. An indolyl ketone called JP18 was identified as a cell cycle regulator, and the underlying mechanism was investigated.