文献类型：期刊文献

英文题名：Mild dealkylative N-nitrosation of N,N-dialkylaniline derivatives for convenient preparation of photo-triggered and photo-calibrated NO donors

作者：Qiu, Shaobing[1];Guo, Chunlei[1];Wang, Mingkang[1];Sun, Zhenglong[2];Li, Hui[2];Qian, Xuhong[1,3];Yang, Youjun[1,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, SIBET, Suzhou 215163, Jiangsu, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：5

期号：22

起止页码：3206

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184606061777);WOS:【SCI-EXPANDED(收录号:WOS:000449412800001)，CCR-EXPANDED(收录号:WOS:000449412800001)】；

基金：The work is financially supported by the National Natural Science Foundation of China (No. 21572061) and the Fundamental Research Funds for the Central Universities (No. WY1516017).

语种：英文

外文关键词：Amines

摘要：N-Nitroso push-pull dyes are unique NO donors, whose NO release is triggered by light and accompanied by a concomitant fluorescence turn-on. Their synthesis involves nitrosation of the corresponding secondary amines, which, however, are not readily available. In this manuscript, we developed a mild, convenient and high-yielding preparation of N-nitroso aryl amines via dealkylative N-nitrosation of tertiary amines. This method is readily employed for the preparation of N-nitrosated rhodamine and coumarin dyes, whose potential as novel NO donors were showcased in cultured cell lines.