文献类型：期刊文献

英文题名：Fabrication and clinical application of easy-to-operate pre-cured CPC/rhBMP-2 micro-scaffolds for bone regeneration

作者：Lin, Dan[1,2,3];Zhang, Jing[1,3];Bai, Feng[5];Cao, Xuehua[1,2];Fan, Cunyi[6];Yuan, Yuan[1,2,3];Wang, Jinwu[4];Zhang, Jian[7];Liu, Changsheng[1,2,3]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Box 112,130 Meilong Rd, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Box 112,130 Meilong Rd, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Minist Educ, Engn Res Ctr Biomed Mat, Box 112,130 Meilong Rd, Shanghai 200237, Peoples R China;[4]Shanghai Jiao Tong Univ, Dept Orthopaed Surg, Peoples Hosp 9, Room 703,Bldg 3,639 Zhizaoju Rd, Shanghai 200011, Peoples R China;[5]451st Mil Hosp, Dept Orthoped, Xian 710054, Shaanxi, Peoples R China;[6]Shanghai Jiao Tong Univ, Peoples Hosp 6, Shanghai 200233, Peoples R China;[7]Zhongshan Hosp Shanghai, Shanghai 200032, Peoples R China

年份：2016

卷号：8

期号：3

起止页码：1379

外文期刊名：AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000375265200006)】；

基金：This work was supported by grants from the National Basic Research Program of China (973 Program, No. 2012CB933600), the 111 Project (B14018), the National Natural Science Foundation of China (No. 31330028 and 31470924). The pilot clinical trial of CPC/rhBMP-2 microffolds as bone substitute for bone regeneration has been registered at clinicaltrials.gov (ID: NCT02609074).

语种：英文

外文关键词：CPC; rhBMP-2; bone regeneration; scaffolds

摘要：Bone tissue engineering scaffolds loading growth factors have been considered as the most perspective among all bone substitutes, yet little progress of its clinical translation has been made. The concept of "micro-scaffolds" was proposed in this study to provide a trajectory to the clinical translation of porous scaffolds. Combining CPC and rhBMP-2, a pre-cured CPC/rhBMP-2 micro-scaffold has been successfully developed and further applied as an easy-to-operate filler for bone regeneration in a pilot clinical study. The results demonstrated superior overall performances of CPC/rhBMP-2 microffolds to traditional therapies, with not only shortened repairing time and improved repairing qualities, but also the potential in treating fractures that are most challenging for current therapies. This pilot clinical study of CPC/rhBMP-2 microffolds further promoted the clinical translation of porous scaffolds for bone regeneration, and provided new insights for future development of artificial bone substitutes.