文献类型：期刊文献

英文题名：In-situ extraction and separation of salvianolic acid B from Salvia miltiorrhiza Bunge by integrated expanded bed adsorption

作者：Zhang, Min[1];Yang, Huihua[2];Chen, Xian[1];Zhou, Yongchuan[1];Zhang, Hongyang[3];Wang, Yuerong[3];Hu, Ping[3]

机构：[1]E China Univ Sci & Technol, Modern Engn Ctr Tradit Chinese Med, Sch Pharm, Shanghai 200237, Peoples R China;[2]Guilin Univ Elect Technol, Coll Comp Sci & Control, Guilin 541004, Peoples R China;[3]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2011

卷号：80

期号：3

起止页码：677

外文期刊名：SEPARATION AND PURIFICATION TECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000294381800034)】；

基金：This research was funded by the National Natural Science Foundation of China (Nos. 30860381, 21006023), Shanghai Science and Technology Commission Project (No. 08DZ1971100) and Shanghai-Unilever Research and Development Fund (No. 08520750300).

语种：英文

外文关键词：In-situ product removal; Expanded bed adsorption; Integration; Salvia miltiorrhiza Bunge; Salvianolic acid B

摘要：This article describes the development of an integrated expanded bed extraction and separation method for in-situ recovery of salvianolic acid B from Salvia miltiorrhiza Bunge. Twenty-five grams of the herb was extracted in a dynamic extraction column for 3 h, while the target was simultaneously absorbed onto an expanded bed column without any further processing. Then, the expanded bed column was eluted with 1 bed volume (BV) of water and 5 BVs of 50% (v/v) ethanol aqueous solution with a flow rate of 2.4 BV/h. From this, 1438.8 mg of salvianolic acids, containing 55.7% of pure salvianolic acid B, was harvested with an 88.0% recovery. Six evaluation parameters - purity, recovery, process throughput, process efficiency, process environmental impact and general process evaluation - were used as indices for evaluation of different methods. The results indicate that the in-situ method we have developed is a promising process for the recovery of salvianolic acid B from the herb of S. miltiorrhiza Bunge. (C) 2011 Elsevier B.V. All rights reserved.