文献类型：期刊文献

英文题名：A glaucoma micro-stent with diverging channel and stepped shaft structure based on microfluidic template processing technology

作者：Wang, Chen[1];Wang, Fule[1];Liao, Yunru[2,3];Zuo, Chengguo[2];Lin, Mingkai[2];Wang, Kemin[4];Ren, Dongni[4];Zhang, Hongbo[1];Yin, Ruixue[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, 7 Jinsui Rd, Guangzhou 510060, Peoples R China;[3]Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Ophthalmol, Guangzhou, Peoples R China;[4]Mingche Biotechnol Co Ltd, Suzhou 215000, Peoples R China

年份：2024

卷号：23

期号：1

外文期刊名：BIOMEDICAL ENGINEERING ONLINE

收录：;EI(收录号：20243116792144);WOS:【SCI-EXPANDED(收录号:WOS:001277798900001)】；

基金：The authors thank Mingche Biology (Suzhou) Co., Ltd. for its financial support.

语种：英文

外文关键词：Glaucoma; MIGS; Drainage stent; Microfluidic channel processing; PDMS; Drainage efficiency

摘要：BackgroundMinimally invasive glaucoma surgery (MIGS) has experienced a surge in popularity in recent years. Glaucoma micro-stents serve as the foundation for these minimally invasive procedures. Nevertheless, the utilization of these stents still presents certain short-term and long-term complications. This study aims to elucidate the creation of a novel drainage stent implant featuring a diverging channel, produced through microfluidic template processing technology. Additionally, an analysis of the mechanical properties, biocompatibility, and feasibility of implantation is conducted.ResultsThe stress concentration value of the proposed stent is significantly lower, approximately two to three times smaller, compared to the currently available commercial XEN gel stent. This indicates a stronger resistance to bending in theory. Theoretical calculations further reveal that the initial drainage efficiency of the gradient diverging drainage stent is approximately 5.76 times higher than that of XEN stents. Notably, in vivo experiments conducted at the third month demonstrate a favorable biocompatibility profile without any observed cytotoxicity. Additionally, the drainage stent exhibits excellent material stability in an in vitro simulation environment.ConclusionsIn summary, the diverging drainage stent presents a novel approach to the cost-effective and efficient preparation process of minimally invasive glaucoma surgery (MIGS) devices, offering additional filtering treatment options for glaucoma.