文献类型：期刊文献

英文题名：Tetrahydroindeno[1′,2′:4,5]pyrrolo[1,2-a]imidazol-5(1H)-ones as Novel Neonicotinoid Insecticides: Reaction Selectivity and Substituent Effects on the Activity Level

作者：Chen, Nanyang[1];Meng, Xiaoqing[1];Zhu, Fengjuan[1];Cheng, Jiagao[1];Shao, Xusheng[1];Li, Zhong[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg Technol, Shanghai 200237, Peoples R China

年份：2015

卷号：63

期号：5

起止页码：1360

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20150700527353);WOS:【SCI-EXPANDED(收录号:WOS:000349576800006)】；

基金：We thank the National Natural Science Foundation of China (21372079 and 21472046), National High Technology Research Development Program of China (863 Program, 2011AA10A207), Shanghai Pujiang Program (14PJD012), Key Projects in the National Science & Technology Pillar Program (2011BAE06B05), and the Fundamental Research Funds for the Central Universities (222201414015) for financial support. This work was also partly supported by Australia DC Foundation.

语种：英文

外文关键词：tetrahydroindeno[1 ',2 ':4,5]pyrrolo[1,2-a]imidazol-S(1H)-one; insecticide; activity; synthesis

摘要：Tetraheterocyclic tetrahydroindeno[1',2':4,5]pyrrolo[1,2-a]imidazol-5(1H)-one derivatives as novel neonicotinoid candidates were designed and prepared by selective etherification, chlorination and esterification of ninhydrin-heterocyclic ketene aminals adducts. Some of the designed compounds showed excellent insecticidal activity against cowpea aphids (Aphis craccivora), brown planthopper (Nilaparvata lugens), and armyworm (Mythimna separata). In particular, the activity against armyworm (Mythimna separata) improved a lot in contrast with that of imidacloprid and cycloxaprid. The research here provides a novel neonicotinoid chemotype for further development.