文献类型：期刊文献

英文题名：Resonance Raman characterization of mononuclear heme-peroxo intermediate models

作者：Ohta, Takehiro[1,2];Liu, Jin-Gang[1,2,3];Naruta, Yoshinori[1,2]

机构：[1]Kyushu Univ, Inst Mat Chem & Engn, Fukuoka 8128581, Japan;[2]Kyushu Univ, Int Inst Carbon Neutral Energy Res, Fukuoka 8128581, Japan;[3]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2013

卷号：257

期号：2

起止页码：407

外文期刊名：COORDINATION CHEMISTRY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000312762200008)】；

基金：This work was financially supported by Grants-in-Aid for Young Scientists (B) (no. 21750064) from JSPS (to TO), Grant-in-Aid for Scientific Research (C) ( no. 24550080) from JSPS (to TO), MEXT project of Integrated Research on Chemical Synthesis (to TO and YN), Innovative Areas (no. 20200050) from MEXT (to JGL and TO), and the Elemental Science and Technology Project from MEXT (to YN).

语种：英文

外文关键词：Resonance Raman spectroscopy; Dioxygen activation; Heme enzyme; Peroxo intermediate; Bioinspired molecular catalyst

摘要：Recent advances in understanding the structural properties of mononuclear heme-peroxo intermediates are reviewed. The peroxo adducts of hemes are pivotal intermediates generated in the active site of heme enzymes, which catalyze dioxygen activation. The transient nature of the peroxo intermediates under physiological conditions makes isolation and spectroscopic characterizations difficult. Thus, our aim was to generate and capture peroxo intermediates using specifically designed porphyrin complexes at low temperatures, where the cryogenic spectroscopic analyses were performed. Our studies revealed the first reliable resonance Raman (RR) evidence for heme-peroxo intermediate models and provided important insight into the structural mechanism of side-on and end-on (hydro)peroxo-bound hemes. (C) 2012 Elsevier B.V. All rights reserved.