文献类型：期刊文献

英文题名：Micro/Nanospheres Generation by Fluid-Fluid Interaction Technology: A Literature Review

作者：Lei, Lei[1,2];Bergstrom, Don[2];Zhang, Bing[3];Zhang, Hongbo[1];Yin, Ruixue[1];Song, Ki-Young[4];Zhang, Wenjun[1,2,3]

机构：[1]East China Univ Sci & Technol, Coll Mech & Power Engn, CISR Lab, POB 200237, Shanghai, Peoples R China;[2]Univ Saskatchewan, Dept Mech Engn, POB S7N 2R6, Saskatoon, SK, Canada;[3]Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK, Canada;[4]Karolinska Inst, Stockholm, Sweden

年份：2017

卷号：11

期号：1

起止页码：15

外文期刊名：RECENT PATENTS ON NANOTECHNOLOGY

收录：;EI(收录号：20170603332139);WOS:【SCI-EXPANDED(收录号:WOS:000397249900003)】；

基金：The authors want to thank the financial support from SHRF (Saskatchewan Health Research Foundation) Phase I project grant to the corresponding author. The first and third authors would like to thank the financial support from China Scholarship Council.

语种：英文

外文关键词：Fluid-fluid interaction; micro/nanosphere generation; microfluidic devices; microsphere generation principle; modeling methods; multiphase flow

摘要：This review focuses on the fundamental fluid mechanics which governs the generation of micro/nanospheres. The micro/nanosphere generation process has gathered significant attention in the past two decades, since micro/nanospheres are widely used in drug delivery, food science, cosmetics, and other application areas. Many methods have been developed based on different operating principles, such as microfluidic methods, electrospray methods, chemical methods, and so forth. This paper focuses on microfluidic methods. Although the structure of the microfluidic devices may be different, the operating principles behind them are often very similar. Following an initial discussion of the fluid mechanics related to the generation of microspheres, various design approaches are discussed, including T-junction, flow focusing, membrane emulsification, modified T-junction, and double emulsification methods. The advantages and problems associated with each method are also discussed. Next, the most commonly used computational fluid dynamics (CFD) methods are reviewed at three different levels: microscopic, mesoscopic, and macroscopic. Finally, the issues identified in the current literature are discussed, and some suggestions are offered regarding the future direction of technology development related to micro/nanosphere generation. Few relevant patents to the topic have been reviewed and cited.