文献类型：期刊文献

中文题名：Advancing homogeneous networking principles for the development of fatigue-resistant,low-swelling and sprayable hydrogels for sealing wet,dynamic and concealed wounds in vivo

作者：Yi Zhang[1];Yanjun Pan[2];Ronghang Chang[1];Kangli Chen[1];Kun Wang[1];Haoqi Tan[3];Meng Yin[2];Changsheng Liu[1];Xue Qu[1,4,5]

机构：[1]Key Laboratory for Ultrafine Materials of Ministry of Education,School of Material Science and Engineering,Frontiers Science Center for Materiobiology and Dynamic Chemistry,East China University of Science and Technology,Shanghai 200237,China;[2]Department of Cardiothoracic Surgery,Shanghai Children’s Medical Center,School of Medicine,Shanghai Jiao Tong University,1678 Dong Fang Road,Shanghai 200127,China;[3]Suzhou Innovation Center of Shanghai University,Shanghai University,Suzhou 215000,Jiangsu,China;[4]Wenzhou Institute of Shanghai University,Wenzhou,325000,China;[5]Shanghai Frontier Science Center of Optogenetic Techniques for Cell Metabolism Shanghai,200237,China

年份：2024

期号：4

起止页码：150

中文期刊名：Bioactive Materials

外文期刊名：生物活性材料（英文）

收录：Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National key research and development program(2021YFB3800800);the National Natural Science Foundation of China(31922041,11932012,32171341,82202334);the 111 Project(B14018);Excellence Project of Shanghai Municipal Health Commission(20234Z0003);the Science and Technology Innovation Project and Excellent Academic Leader Project of Shanghai Science and Technology Committee(21S31901500,21XD1421100)are acknowledged.

语种：英文

中文关键词：Sprayable hydrogel sealants;Homogeneous network;Fatigue-resistance;Low swelling;Wet dynamic and concealed wound

摘要：Effective sealing of wet,dynamic and concealed wounds remains a formidable challenge in clinical practice.Sprayable hydrogel sealants are promising due to their ability to cover a wide area rapidly,but they face limitations in dynamic and moist environments.To address this issue,we have employed the principle of a homogeneous network to design a sprayable hydrogel sealant with enhanced fatigue resistance and reduced swelling.This network is formed by combining the spherical structure of lysozyme(LZM)with the orthotetrahedral structure of 4-arm-polyethylene glycol(4-arm-PEG).We have achieved exceptional sprayability by controlling the pH of the precursor solution.The homogeneous network,constructed through uniform cross-linking of amino groups in protein and 4-arm-PEG-NHS,provides the hydrogel with outstanding fatigue resistance,low swelling and sustained adhesion.In vitro testing demonstrated that it could endure 2000 cycles of underwater shearing,while in vivo experiments showed adhesion maintenance exceeding 24 h.Furthermore,the hydrogel excelled in sealing leaks and promoting ulcer healing in models including porcine cardiac hemorrhage,lung air leakage and rat oral ulcers,surpassing commonly used clinical materials.Therefore,our research presents an advanced biomaterial strategy with the potential to advance the clinical management of wet,dynamic and concealed wounds.