文献类型：期刊文献

英文题名：Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration

作者：Zhou, Panyu[1];Wang, Jiayi[2,3];Wang, Hongrui[1];Pan, Hao[2,3];Shi, Hengsong[2,3];Fu, Yu[4];Yuan, Yuan[2,3];Wang, Yang[1];Gan, Qi[2,3];Liu, Changsheng[2,3]

机构：[1]Naval Med Univ, Changhai Hosp, Dept Orthoped, Shanghai 200082, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]Tongji Univ, Sch Aerosp Engn & Appl Mech, Zhangwu Rd 100, Shanghai 200092, Peoples R China

年份：2025

卷号：6

期号：1

起止页码：95

外文期刊名：SMART MATERIALS IN MEDICINE

收录：EI(收录号：20251118025807);WOS:【ESCI(收录号:WOS:001815998300001)】；

基金：This work was supported by the National Key R&D Program of China (No. 2022YFB3804300), the National Natural Science Foundation of China (No. T2288102, 32071337), Shanghai Pujiang Program (20PJ1402600) and the Naval Medical University Science Youth Cultivation Program Incubation Project. This study was also supported by "the Fundamental Research Funds for the Central Universities".

语种：英文

外文关键词：Biomimetic; 3D printing; Bone tissue regeneration

摘要：3D printing is regarded as an ideal method for large-scale bone defect repair. A rapid curing rate and strong mechanical properties throughout the product's shelf life are key development goals in 3D-printed bone repair biomaterials. To achieve this goal, we developed a 3D-printable organic/inorganic composite ink featuring rapid curing and highly customizable properties. After 3D printing, the nanocomposite ink of poly (glyceryl sebacate)-2chlorocinnamoyl chloride/beta-tricalcium phosphate (PGS-CC/beta-TCP) undergoes short-term light crosslinking to form a biomimetic network of inorganic-organic composite materials. The resulting bone repair scaffold possesses excellent mechanical properties, significantly promotes cell adhesion and proliferation, and demonstrates good in vitro osteogenic activity, angiogenic performance, and mineralization capability. Moreover, the PGS-CC/beta-TCP 3D-printed scaffold exhibits good degradation performance, retaining its mechanical properties even after four weeks of degradation. The PGS-CC(1:2)/beta-TCP composite scaffold can effectively repair severe cranial bone defects in rats, showing optimal in vivo osteogenic and degradation performance at 6 and 12 weeks. With these advantages, this innovative 3D-printed biomaterial has great clinical application prospects for large segment bone repair and provides new opportunities for other complex reconstructions.