文献类型：期刊文献

英文题名：Iron-Catalyzed Anti-Markovnikov Hydroamination of Vinylpyridines

作者：Peng, Yahui[1,2];Qin, Cong[1,2];Chen, Xiaobei[1,2];Li, Jianjun[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioengn Reactor, 130 Mei Long Rd, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2017

卷号：6

期号：6

起止页码：694

外文期刊名：ASIAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000405134900012)，CCR-EXPANDED(收录号:WOS:000405134900012)】；

基金：Financial support of this research from the National Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and East China University of Science and Technology, and the China 111 Project (Grant B07023) is gratefully acknowledged.

语种：英文

外文关键词：anti-Markovnikov; azoles; hydroamination; iron; vinylpyridines

摘要：An efficient, green and atom-economical iron-catalyzed hydroamination of vinylpyridines with azoles has been developed. This reaction works smoothly for a diverse range of vinylpyridines and azoles, including diazoles and triazoles. The reaction was catalyzed by 5 mol% FeCl3 in toluene at 110 degrees C for 3 h to afford the anti-Markovnikov hydroamination products in moderate to excellent yields and excellent selectivities.