文献类型：期刊文献

英文题名：Amphiphilic methoxy poly(ethylene glycol)-b-poly(carbonate-selenide) with enhanced ROS responsiveness: Facile synthesis and oxidation process

作者：Li, Siqi[1];Song, Fangqin[1];Sun, Chuanhao[1];Hu, Jieni[1];Zhang, Yan[1,2,3]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Fudan Univ, Key Lab Smart Drug Delivery, Minist Educ, Dept Pharmaceut,Sch Pharm, Shanghai, Peoples R China;[3]Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai, Peoples R China

年份：2021

卷号：159

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：;EI(收录号：20214611147988);WOS:【SCI-EXPANDED(收录号:WOS:000702536200004)】；

基金：This work was supported by National Natural Science Foundation of China (52073093, 51873062) .

语种：英文

外文关键词：Ring-opening polymerization; Selenium-containing; ROS-responsive; Self-assembly

摘要：The synthesis of ROS-responsive polymers has attracted much attentions in recent years. Herein, we report a series of amphiphilic methoxy poly(ethylene glycol)-b-poly(carbonate-selenide)s (mPEG(45)-b-poly(MSe)(m), m = 12, 24, 36, 48, 60) by introducing selenide groups onto the backbone via one-pot lipase-catalyzed ring-opening polymerization (ROP), the synthesized amphiphilic polymers with enhanced ROS-responsiveness can self-assemble to form nanoparticles. Nuclear Magnetic Resonance (NMR), Gel Permeation Chromatography (GPC) and Fourier Transform Infrared (FTIR) are employed to confirm the structure of the polymers. Besides, the oxidation process of mPEG(45)-b-poly(MSe)(m) nanoparticles is also clarified. Ultraviolet-visible Spectrophotometer (UV-Vis), Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) are further utilized to demonstrate the turbidity, morphology and size changes under oxidization, proving that the selenide groups endow the mPEG(45)-b-poly(MSe)(m) nanoparticles with enhanced ROS-response properties. Therefore, the above studies highlight the synthesized ROS-responsive polymers and provided a potential material for further applications.