文献类型：期刊文献

英文题名：Regulating the molecule and electrode interface of a single-molecule junction via the side chain

作者：Li, Yunpeng[1];Tang, Ajun[1];Wang, Rui[1];Li, Yingjie[1];Ma, Chaoqi[1];Li, Hongxiang[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat,Inst Fine Chem,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2023

卷号：59

期号：31

起止页码：4628

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20231513866051);WOS:【SCI-EXPANDED(收录号:WOS:000960146500001)】；

基金：This work was supported by the National Natural Science Foundation of China (21875279, 22075080, and 52273176), the Shanghai Municipal Science and Technology Major Project(grant no. 2018SHZDZX03), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Amino acids - Electrodes - Gold compounds

摘要：Here, we report that the molecule-electrode interface of a single-molecule junction can be regulated by a side chain. Based on this regulation, a single-molecule junction probe, PyCHO, was developed, which could distinguish cysteine (Cys) and homocysteine (Hcy) with high selectivity and sensitivity. PyCHO reacts with Cys/Hcy at ambient conditions to form thiazolidine/thiazinane products PyCHO+Cys/PyCHO+Hcy. Single molecular conductance measurement shows PyCHO+Cys and PyCHO+Hcy have different conductance. Control experiments and theoretical results reveal that the side thiazolidine/thiazinane rings have a distinct effect on the Au-p interaction of the pyridine anchor, resulting in their different conductances.