文献类型：期刊文献

中文题名：A Simple and “Green” Method for Synthesis of Magnetic Hollow Silica Spheres and Its ⁹⁹Tc^mLabeled Targeting Studies

英文题名：A Simple and “Green” Method for Synthesis of Magnetic Hollow Silica Spheres and Its ⁹⁹Tc^mLabeled Targeting Studies

作者：Yicheng Liu[1];Xiazhang Li[2];Jen Sloppy[3];Yan Huang[1];Pingping Yao[1];Junya Yang[1];Yuxiang Yang[1]

机构：[1]School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, China;[2]School of petrochemical engineering, Changzhou University, Changzhou, China;[3]Department of Materials Science and Engineering, University of Delaware, Newark, DE, USA

年份：2017

卷号：7

期号：1

起止页码：1

中文期刊名：Open Journal of Inorganic Chemistry

外文期刊名：无机化学期刊（英文）

收录：PubMed

语种：英文

中文关键词：A;Simple;and;“Green”;Method;Magnetic;Hollow;Silica;Spheres;Magnetic;Targeting;Iron;Salts;Radioisotope;99Tcm

外文关键词：A Simple and “Green” Method;Magnetic Hollow Silica Spheres;Magnetic Targeting;Iron Salts;Radioisotope 99Tcm

摘要：The magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were prepared by a simple and “green” method using functionalized SiO2 spheres as templates. Magnetic particles (Fe3O4) were deposited on the SiO2 surface by varying the molar ratio of [Fe2+]/[Fe3+] and the molar concentration of iron salts. The obtained magnetic hollow silica spheres exhibited a super-paramagnetic behavior at room temperature. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray powder scattering (XRD) were applied to characterize the MHSS. Besides, their unit cell parameters are calculated according to results indexing to XRD, the MHSS sample prepared at 0.10 M iron salts and 2:1 molar ratio of [Fe2+]/[Fe3+] has a largest cell angle (β) of unit cell. Due to large hollow cavity space and super-paramagnetic characteristics, the inner amino-functionalized MHSS could be labeled with radioisotope 99Tcm to study the MHSS’s magnetic targeting distribution in vivo. These results indicate that the MHSS has potential in the magnetic targeted drug delivery system which reduces the damage to normal cells and improves the therapeutic effect of cancer.
The magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were prepared by a simple and “green” method using functionalized SiO2 spheres as templates. Magnetic particles (Fe3O4) were deposited on the SiO2 surface by varying the molar ratio of [Fe2+]/[Fe3+] and the molar concentration of iron salts. The obtained magnetic hollow silica spheres exhibited a super-paramagnetic behavior at room temperature. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray powder scattering (XRD) were applied to characterize the MHSS. Besides, their unit cell parameters are calculated according to results indexing to XRD, the MHSS sample prepared at 0.10 M iron salts and 2:1 molar ratio of [Fe2+]/[Fe3+] has a largest cell angle (β) of unit cell. Due to large hollow cavity space and super-paramagnetic characteristics, the inner amino-functionalized MHSS could be labeled with radioisotope 99Tcm to study the MHSS’s magnetic targeting distribution in vivo. These results indicate that the MHSS has potential in the magnetic targeted drug delivery system which reduces the damage to normal cells and improves the therapeutic effect of cancer.