文献类型：期刊文献

英文题名：Fabricated technology of biomedical micro-nano hydrogel

作者：Yang, Shu[1,2];Wang, Fan[1];Han, Huijie[3];Santos, Helder A.[3];Zhang, Yu[4];Zhang, Hongbo[4];Wei, Jie[2];Cai, Zhengwei[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Prevent & Treatment Bone & Joint, Shanghai Inst Traumatol & Orthopaed,Ruijin Hosp,De, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[3]Univ Groningen, Univ Med Ctr Groningen, WJ Korf Inst Biomed Engn & Mat Sci, Dept Biomed Engn, NL-9713 AV Groningen, Netherlands;[4]Abo Akad Univ, Pharmaceut Sci Lab, Turku 20520, Finland

年份：2023

卷号：2

起止页码：31

外文期刊名：BIOMEDICAL TECHNOLOGY

收录：WOS:【ESCI(收录号:WOS:001523595300001)】；

基金：This research is funded by National Natural Science Foundation of China General Program (32171340, 32101104) , Shanghai Municipal Health Planning Commission (202140127) .

语种：英文

外文关键词：Hydrogel; Biopolymers; Microgels; Nanogels; Tissue engineering

摘要：Micro-nano hydrogel is a novel functional material that has attracted extensive attention in various fields. Due to the size of micron and nano level, high water content and high specific surface area, the micro-nano hydrogels can achieve minimally invasive repair and are considered as promising agents in tissue repair engineering. In this review, we summarize the design and development of micro-nano hydrogels for biomedical applications, first introduce biopolymers for the synthesis of hydrogels, then introduce the preparation technologies of microgels and nanogels respectively, and systematically summarize the application characteristics and forms of different preparation technologies. Finally, the latest application progresses of microgels in local drug delivery, bone tissue repair, soft tissue repair and immunomodulation are introduced in detail, as well as the latest application progress of nanohydrogels in cartilage repair, antibacterial, antitumor/cancer nerve repair and prevention and diagnosis of diseases, and the key research directions of micro-nano hydrogel preparation technologies in the future are clarified.