文献类型：期刊文献

英文题名：Asymmetric Synthesis of Spirooxindole β-lactams via Isothiourea-catalyzed Mannich/lactamization Reaction of Aryl Acetic Acids with Isatin-derived Ketimines

作者：Jin, Jing-Hai[1,2];Zhao, Jianhong[1,2];Yang, Wu-Lin[1,2];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharmsign, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：361

期号：7

起止页码：1592

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000463734200014)，CCR-EXPANDED(收录号:WOS:000463734200014)】；

基金：This work is supported by The Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (No. 21372074, 21572053).

语种：英文

外文关键词：[2+2] annulation; asymmetric synthesis; HBTM; Mannich/lactamization reaction; spirooxindole beta-lactams

摘要：An efficient [2+2] annulation strategy that isothiourea catalyst homobenzotetramisole (HBTM)-catalyzed Mannich/lactamization cascade reaction of carboxylic acids with isatin-derived ketimines has been disclosed. This protocol affords a range of structurally diverse spirooxindole beta-lactams bearing two vicinal stereogenic centers in good to high yields with good to excellent stereoselectivities.