文献类型：期刊文献

英文题名：Colorimetric and fluorescent "turn-off" sensors for Hg2+based on mercury-induced hydrolysis of dithioacetals

作者：Luo, Yuqi[1];Yang, Wenyi[1];Bo, Yuanfang[1];Song, Runze[1];Zhang, Weibing[1];Qian, Junhong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2026

卷号：348

外文期刊名：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

收录：;EI(收录号：20254819595443);WOS:【SCI-EXPANDED(收录号:WOS:001628340700003)】；

基金：This work was financially supported by National Key Research and Development Program of China (2022YFD1700800) .

语种：英文

外文关键词：Fluorescent probe; Coumarin; Hg2+; Dithioacetal; Heterocyclic stability

摘要：Three fluorescent probes for Hg2+, Hg-5, Hg-6, and Hg-7, were designed and synthesized by incorporating a cyclic dithioacetal recognition unit to an N, N-diethyl-7-amino-coumarin fluorophore. Under physiological pH conditions, all the probes demonstrated high selectivity and strong anti-interference capability toward Hg2+ over other competing ions. These probes enable both colorimetric and fluorescent quantification of Hg2+ in aqueous solution and show promising potential for confocal fluorescence imaging of Hg2+ in living cells. Notably, the ring size of the dithioacetal moiety significantly influences the response kinetics due to steric effect and heterocyclic stability. The response time toward Hg2+ decreases in the order of Hg-5 > Hg-6 > Hg-7. In addition of fast responses to Hg2+ (response time less than 1 min), excellent linear relationships between the absorbance ratio A(446)/A(400) as well as the fluorescence intensity at 485 nm of Hg-7 and Hg2+ concentration were observed over the range of 0.5-20 mu M (R-2 = 0.99), and the detection limit (LOD) for Hg2+ was calculated to be 0.04 mu M.