文献类型：期刊文献

英文题名：Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

作者：Xiang, Hui-Jing[1,2];Deng, Qiao[1,2];An, Lu[3,4];Guo, Min[1,2];Yang, Shi-Ping[3,4];Liu, Jin-Gang[1,2]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat MOE, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2016

卷号：52

期号：1

起止页码：148

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000366856900026)】；

基金：This study was financially supported by the NSF of China (21271072, 21571062), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning, and sponsored by the Shanghai Pujiang Program (13PJ1401900).

语种：英文

摘要：A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform(Lyso-Ru-NO@FA@C-TiO2) (1) was developed. It selectively targets folate-receptor overexpressed cancer cells and specifically locates within the lysosome organelle to which NO and reactive oxygen species are simultaneously released upon 808 nm NIR light irradiation. The dual-targeted nanoplatform (1) demonstrated the highest anticancer efficacy compared with nontargeted counterparts under NIR light sensitization.