文献类型：期刊文献

英文题名：Inherent anchorages in UiO-66 nanoparticles for efficient capture of alendronate and its mediated release

作者：Zhu, Xiangyang[1];Gu, Jinlou[1];Wang, Yao[1];Li, Bing[1];Li, Yongsheng[1];Zhao, Wenru[1];Shi, Jianlin[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2014

卷号：50

期号：63

起止页码：8779

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000339469900040)】；

基金：This work was financially supported by the Natural Science Foundation of China (51072053, 51372084, and 51132009), the Innovation Program of Shanghai Municipal Education Commission (13zz040) and the Nano-Special Foundation for Shanghai Committee of Science and Technology (12nm0502600).

语种：英文

摘要：Zr-based MOF nanoparticles were applied as efficient carriers for alendronate delivery, and an unprecedented drug loading capacity was achieved thanks to the inherent drug anchorages of Zr-O clusters therein. The encapsulated drug featured with a pH-dependent release profile, and inhibited the growth of cancer cells more efficiently than the free drug.