文献类型：期刊文献

英文题名：Efficient ROS Activation by Highly Stabilized Aqueous Icg Encapsulated Upconversion Nanoparticles for Tumor Cell Imaging and Therapeutics

作者：Wu, Yue[1]; Yuan, Chen[1]; Jia, Xianjing[2]; Zheng, Zhiyuan[1]; Yang, Xijiao[1]; Basak, A. Kayitmazer[3]; Ahmad, Ayyaz[4]; Ramzan, Naveed[5]; Xu, Yisheng[1]

机构：[1] State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai, 200237, China; [2] Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Department of Chemistry, Bogazici University, Istanbul, Turkey; [4] Department of Chemical Engineering, Muhammad Nawaz Sharif University of Engineering and Technology, Multan, Pakistan; [5] Faculty of Chemical, Metallurgical, and Polymer Engineering, University of Engineering & Technology, Lahore, Pakistan

年份：2022

外文期刊名：SSRN

收录：EI(收录号：20220044926)

语种：英文

外文关键词：Biocompatibility - Block copolymers - Diseases - Dye-sensitized solar cells - Energy transfer - Nanoparticles - Polyethylene glycols - Polyethylene oxides - Quenching - Synthesis (chemical) - Tumors

摘要：Dye-sensitized upconversion nanoparticles (UCNPs) have gained significant interests in biological applications. However, previous attempts to utilize these dye-sensitized UCNPs in aqueous environment suffer from dramatic decline of the upconversion luminescence (UCL) intensity and problems with nanoparticles aggregation and water quenching. By employing indocyanine green (ICG) as a hydrophobic amplifier and energy harvester for UCNPs, we use a general, facile and kinetically controlled mixing technology—flash nanoprecipitation (FNP)—to prepare aqueous stable ICG-sensitized UCNPs encapsulated by a biocompatible block copolymer poly (ethylene glycol)-b-poly (lactic-co-glycolic acid (PEG- b -PLGA) to efficiently activate ROS generation for simultaneous cancer cell imaging and treatment. As compared to NPs obtained from traditional drip and stir method (TM), the NPs under high turbulent conditions (high Re ) exhibit smaller size, narrower size distribution, and much higher stability when the UCNP hydrophobicity was enhanced by ICG. The remained UCL intensity was significantly boosted as well as ROS generation through FNP in the presence of ICG, but not for TM samples indicating a superior protection of upconversion NPs from water quenching and the energy transfer between ICG and UCNP was well retained. The efficiency of ROS generation of NPs via FNP evidently increases with the stronger red-light emission of UCNPs, resulting in a high cytotoxicity for SMMC-7721 cells in vitro and good suppression of tumor growth in vivo . The success of NPs by FNP in biological application demonstrates a bright prospect of FNP for synthesis of efficient antitumor nanoparticles. ? 2022, The Authors. All rights reserved.