文献类型：期刊文献

中文题名：当归净油抗衰老及抗炎祛痘功效的体外实验研究

英文题名：In vitro test for examination of anti- senility and anti- inflammatory acne effects of absolute oil from Angelica sinensis(Oliv.) Diels

作者：王玥[1,2,3];于海园[2];施雁勤[1];潘仙华[1];卢艳花[2];曹平[3]

机构：[1]上海应用技术大学,上海201418;[2]华东理工大学生物反应器工程国家重点实验室,上海200237;[3]上海家化(集团)有限公司,上海200082

年份：2017

卷号：47

期号：2

起止页码：87

中文期刊名：日用化学工业

外文期刊名：China Surfactant Detergent & Cosmetics

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD_E2017_2018】；

基金：教育和科研协同创新计划--上海市香料香精及化妆品协同创新中心资助项目(1021ZK162001)

语种：中文

中文关键词：化妆品添加剂;当归;抗衰老;抗炎祛痘;植物天然香料

外文关键词：cosmetic additive ;Angelica sinensis ; anti - senility; anti - inflammatory acne; perfume plants

摘要：通过人真皮成纤维细胞(HDF-a)模型,考察了当归净油对细胞分泌Ⅰ型胶原蛋白(Col-Ⅰ)的影响。结果表明,当归净油在最大安全质量浓度25 mg/L时,能有效增加HDF-a细胞分泌Col-Ⅰ达33.5%。利用痤疮丙酸杆菌刺激人急性单核细胞THP-1,建立了特异性痤疮炎症细胞模型,考察当归净油对细胞分泌炎症因子人白细胞介素1β(IL-1β)的影响。结果表明,当归净油最大安全质量浓度为12.5 mg/L,此时对痤疮丙酸杆菌诱导的THP-1细胞炎症因子IL-1β分泌抑制率高达94.51%,当质量浓度减半为6.25 mg/L时,抑制率为64.34%。当归净油作为一种芳香性中草药,有望成为抗衰老及抗炎祛痘的个人护理天然原料,在化妆品中得到进一步开发和利用。
Via a model of human dermal fibroblasts -adult （HDF -a） ,effects of Angelica sinensis absolute oil （ASO） on the secretion of collagen type I （Col - I ） by the HDF - a cells were examined. Results showed that when the ASO is at its maximum safety mass concentration for the HDF - a cells 25 mg/L, the secretion of Col - I in HDF -a ceils can be effectively increased by 33.5%. In addition, an inflammatory acne model was established by stimulating human acute mononuclear cells THP - 1 cells with Propionibacterium acnes （P. acnes）. Results showed that when ASO is at its maximum safety mass concentration for the THP - 1 cells 12.5 mg/L,the ASO can inhibit the release of inflammatory cytokines IL- 1β from P. aches treated THP- 1 cells by 94.51%. When the mass concentration is halved to 6.25 mg/L, the ASO still can significantly inhibit IL- 1 β secretion by 64. 34%. Hence ,ASO is a natural plant perfume raw material that displays anti -senility and anti - inflammatory acne effects in personal care activities and is expected to be further developed and applied in cosmetics.