文献类型：期刊文献

中文题名：新型类肝素物质的研究——水溶性磺化羟丙基壳聚糖的研制

英文题名：Study on Preparation of Novel Heparinlike Materials——Watersoluble Hydroxylpropylchitosan Sulfat

作者：方波[1];江体乾[1]

机构：[1]华东理工大学化学工程研究所

年份：1998

卷号：24

期号：3

起止页码：286

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;国家哲学社会科学学术期刊数据库;Scopus;北大核心:【北大核心1996】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金

语种：中文

中文关键词：甲壳素;壳聚糖;水溶性壳聚糖;类肝素物质

外文关键词：chitin; chitosan; watersoluble chitosan; chitosan sulfated derivatives; heparinlike materials

摘要：以片状壳聚糖为原料，先制成羟丙基壳聚糖，再以氯磺酸－甲酰胺为磺化试剂，在适当条件下进行磺化，获得了水溶性良好的磺化羟丙基壳聚糖。硫含量ｗＳ为０．０８８～０．１２７。考察了磺化反应条件对硫含量的影响，确立了较优的反应条件。红外光谱分析表明，该衍生物具有类肝素结构，是一种非常有潜力的新型类肝素物质，可望进一步研制成新型类肝素药物。
Chitosan flake could be converted into watesoluble hydroxylproply chitosan, and then reacted with sulfonating agent (composed of chlorosulfonic acid and formamide) under proper conditions, the sulfonated hydroxylpropyl chitosan was obtained successfully. It possesses good watersolubility and its sulfur content is 8.8%～12.7%. The effects of sulfonation conditions on the sulfur content were investigated, and the proper reaction conditions were determined. The results of infrared spectrometry showed that it possesses almost the same structure as heparin does. It is a novel heparinlike material with great promise, and may be further developed into novel heparinlike medicine.