文献类型：期刊文献

英文题名：Organocatalytic Enantioselective Cross-Aldol Reactions of Aldehydes with Isatins: Formation of Two Contiguous Quaternary Centered 3-Substituted 3-Hydroxyindol-2-ones

作者：Xue, Fei[1];Zhang, Shilei[1];Liu, Lu[1];Duan, Wenhu[1];Wang, Wei[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2009

卷号：4

期号：11

起止页码：1664

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20100212624282);WOS:【SCI-EXPANDED(收录号:WOS:000271814800003)】；

基金：Financial support of this research is supported by the School of Pharmacy, East China University of Science and the China 111 Project (Grant No. B07023).

语种：英文

外文关键词：aldehydes; aldol; isatins; organocatalysis

摘要：Good neighbors: Cross-aldol reactions of isatins with aldehydes, catalyzed by (S)-pyrrolidine tetrazole are developed. In the process, two contiguous quaternary centers and one chiral carbon are created simultaneously with good efficiency. ? 2009 Wiley-VCH Verlag GmbH & Co. KGaA.