文献类型：期刊文献

中文题名：A Single-wavelength NIR-triggered Polymer for in Situ Generation of Peroxynitrite (ONOO^(?)) to Enhance Phototherapeutic Efficacy

作者：Xiang Zhang[1];Da-Wei Jiang[1];Guo-Liang Yang[1];Yu-Cheng Zhu[1];Jia Tian[1];Hong-Liang Cao[1];Yun Gao[1];Wei-An Zhang[1]

机构：[1]Shanghai Key Laboratory of Functional Materials Chemistry,East China University of Science and Technology,Shanghai 200237,China

年份：2021

卷号：39

期号：6

起止页码：692

中文期刊名：Chinese Journal of Polymer Science

外文期刊名：高分子科学（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；

基金：by the National Natural Science Foundation of China(No.21875063);the Science and Technology Commission of Shanghai Municipality for the Shanghai International Cooperation Program(No.19440710600).

语种：英文

中文关键词：Peroxynitrite(ONOO^(-));Phototherapy;Cyanine;Napthalimide;Near-infrared

摘要：Phototherapies including photodynamic therapy(PDT)and photothermal therapy(PTT)are the most promising and non-invasive cancer treatments.However,the efficacy of mono-therapy of PDT or PTT is often limited by the phototherapeutic defects such as low light penetration depth of photosensitizers and insufficiency of photothermal agents.Peroxynitrite(ONOO?)has been proved to be an efficient oxidizing and nitrating agent that involves in various physiological and pathological processes.Therefore,ONOO?produced in tumor site could be an effective treatment in cancer therapy.Herein,a novel cyanine dye-based(Cy7)polymer nanoplatform is developed for enhanced phototherapy by in situ producing ONOO?.The Cy7 units in the nanoparticles can not only be served as the photosensitizer to produce reactive oxygen species(ROS)including singlet oxygen and superoxide anion for PDT,but also be used as a heat source for PTT and the release of NO gas from N-nitrosated napthalimide(NORM)at the same time.Since NO can react quickly with superoxide anion to generate ONOO?,the enhanced phototherapy could be achieved by in situ ONOO?produced by PCy7-NO upon exposure to the near infrared(NIR)light.Therefore,the NIR-triggered Cy7-based nanoplatform for ONOO?-enhanced phototherapy may provide a new perspective in cancer therapy.