文献类型：期刊文献

英文题名：Influences of niobium pentoxide on roughness, hydrophilicity, surface energy and protein absorption, and cellular responses to PEEK based composites for orthopedic applications

作者：Ge, Junpeng[1];Wang, Fan[1];Xu, Zhiyan[1];Shen, Xuening[1];Gao, Chao[1];Wang, Dongliang[2];Hu, Gangfeng[3];Gu, Jinlou[1];Tang, Tingting[4];Wei, Jie[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Dept Orthoped Surg, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China;[3]First Peoples Hosp Xiaoshan Dist, 199 Shixinnan Rd, Hangzhou 311200, Zhejiang, Peoples R China;[4]Shanghai Jiao Tong Univ, Shanghai Key Lab Orthopaed Implants, Shanghai Peoples Hosp 9, Dept Orthopaed Surg,Sch Med, Shanghai 200011, Peoples R China

年份：2020

卷号：8

期号：13

起止页码：2618

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20201508391040);WOS:【SCI-EXPANDED(收录号:WOS:000526931600006)】；

基金：Grants were provided by the National Natural Science Foundation of China (81771990 and 81572194), the Key Medical Program of Science and Technology Development of Shanghai (19441906100, 17441900600 and 17441902000), the National key research and development program (2016YFC1102100) and the Opening Project of Shanghai Key Laboratory of Orthopaedic Implants.

语种：英文

外文关键词：Interfacial energy - Proteins - Bone - Cell proliferation - Niobium oxide - Sintering - Sol-gel process - Sol-gels - Cell culture - Surface roughness - Morphology - Stem cells

摘要：To improve the bio-performances of polyetheretherketone (PEEK) for orthopedic applications, submicro-particles of niobium pentoxide (Nb2O5) were synthesized using a sol-gel method, and PEEK/Nb2O5 composites (PNC) with a Nb2O5 content of 25v% (PNC25) and 50v% (PNC50) were fabricated by utilizing a process of pressing-sintering. The results showed that the Nb2O5 particles were not only dispersed in the composites but also exposed on the surface of the composites, which formed submicro-structural surfaces. In addition, the hydrophilicity, surface energy, surface roughness and absorption of proteins of the composites were improved with increasing Nb2O5 content. Moreover, the release of Nb ions with the highest concentration of 5.01 x 10(-6) mol L-1 from the composite into the medium displayed no adverse effects on cell proliferation and morphology, indicating no cytotoxicity. Furthermore, compared with PEEK, the composites, especially PNC50, obviously stimulated adhesion and proliferation as well as osteogenic differentiation of bone mesenchymal stem cells of rats. The results suggested that the incorporation of Nb2O5 submicro-particles into PEEK produced novel bioactive composites with improved surface properties, which played important roles in regulating cell behaviors. In conclusion, the composites, especially PNC50 with good cytocompatibility and promotion of cellular responses, exhibited great potential as implantable materials for bone repair.