文献类型：期刊文献

英文题名：Osteogenesis, vascularization and osseointegration of a bioactive multiphase macroporous scaffold in the treatment of large bone defects

作者：Chu, Linyang[1];Jiang, Guoqiang[2];Hu, Xi-Le[3,4];James, Tony D.[5];He, Xiao-Peng[3,4];Li, Yaping[2];Tang, Tingting[1]

机构：[1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Orthoped Implants, Shanghai Peoples Hosp 9,Dept Orthoped Surg, Shanghai 200011, Peoples R China;[2]Ningbo Univ, Sch Med, Affiliated Hosp, Dept Orthopaed Surg, Ningbo 315211, Zhejiang, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[5]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

年份：2018

卷号：6

期号：25

起止页码：4197

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20182705399675);WOS:【SCI-EXPANDED(收录号:WOS:000436570500003)】；

基金：This research was financially supported by the National Key R&D Program (2016YFC1102100), the China Postdoctoral Science Foundation (2018M630407), the Ningbo Municipal Natural Science Foundation (2010C500009) and the Zhejiang Natural Science Foundation (2017LY17H060001). X.-P. He thanks the Natural Science Foundation of China (21722801 and 21572058) and the Shanghai Rising-Star Program (16QA1401400) (to X.-P. He) for generous financial support. The Catalysis And Sensing for our Environment (CASE) network is thanked for research exchange opportunities. T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and ECUST for a guest professorship.

语种：英文

外文关键词：Scaffolds (biology) - Computerized tomography

摘要：Bone grafting remains the method of choice for the majority of surgeons in the treatment of large bone defects, since it fills spaces and provides support to enhance biological bone repair. Recently, we have reported our research on a bioactive multiphase macroporous scaffold with interconnected porous structures and nano-crystal surface microstructures that can release bioactive ions. Moreover, we demonstrated the excellent in vitro biological activity of the scaffold. In this study, we set out to evaluate the in vivo osteogenesis and vascularization of the scaffold in the treatment of large bone defects (10 mm radial bone defect in rabbits). In comparison with the control group, X-ray and micro-CT results at the 4th and 8th week post-surgery reveal that the bioactive scaffold displayed an enhanced level of new bone and vessel formation. Histological results at the same weeks indicated improved bone formation, osseointegration and new vessel ingrowth inside the bioactive scaffold. These findings establish a good foundation for the potential clinical validation of the bioactive macroporous biomaterial scaffold for use as a bone substitute or in tissue engineering.