文献类型：期刊文献

英文题名：Multifunctional gold nanostar-based nanocomposite: Synthesis and application for noninvasive MR-SERS imaging-guided photothermal ablation

作者：Gao, Yongping[1];Li, Yongsheng[1];Chen, Jianzhuang[1];Zhu, Shaojia[2];Liu, Xiaohang[3];Zhou, Liangping[3];Shi, Ping[2];Niu, Dechao[1];Gu, Jinlou[1];Shi, Jianlin[1,4]

机构：[1]E China Univ Sci & Technol, Lab Low Dimens Mat Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Shanghai Canc Hosp, Dept Radiol, Shanghai 200032, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Ceram, Shanghai 200050, Peoples R China

年份：2015

卷号：60

起止页码：31

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20152300925196);WOS:【SCI-EXPANDED(收录号:WOS:000356737800004)】；

基金：This work was financially supported by the 973 Program (Grant No. 2012CB933602); the National Natural Science Foundation of China (Grant Nos. 51172070, 51132009, 51202068, 51472085, 5141101086); Shu Guang project (Grant No. 11SG30); The Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Nanocomposite; Gold; MRI; SERS; Photothermal therapy

摘要：We report here the design and facile synthesis of multifunctional gold nanostars based nanocomposites (MGSNs) through direct organosilica coating onto anisotropic gold nanostars followed by the conjugation of Gd chelates. The as-synthesized MGSNs possess strong NIR absorbance, SERS signal and enhanced T-1- MR imaging capability with excellent dispersivity and uniform size, as well as great photothermal stability and Raman stability under photothermal conditions. Importantly, MGSNs present excellent performance in vivo after their intravenous injection for both MR and SERS imaging and the high efficiency for killing tumor cells through photothermal ablation with NIR irradiation. A combination of the high spatial resolution of MR and the exciting sub-cell-level sensitivity and resolution of SERS can provide comprehensive information about the tumor to achieve the optimized therapeutic outcome. Therefore, MGSNs are of great potential as a multifunctional nanoplatform for MR-SERS bimodal imaging-guided, focused photothermal tumor therapy. (C) 2015 Elsevier Ltd. All rights reserved.