文献类型：期刊文献

中文题名：An acidic medium-compatible deep-near-infrared dye for in vivo imaging

作者：Yan Dong[1];Ye Zou[1];Xiaotong Jia[1];Lei Yin[1];Weiwei He[1];Xiao Luo[1];Xuhong Qian[1];Youjun Yang[1]

机构：[1]School of Pharmacy,East China University of Science and Technology,Shanghai,China

年份：2023

卷号：1

期号：1

起止页码：97

中文期刊名：Smart Molecules

外文期刊名：智能分子（英文）

基金：supported by the National Key Research and Development Program of China(No.2022YFD17800);the National Natural Science Foundation of China(Nos.22078098,and 22278138);the Shanghai Academic Technology Research Leader(22XD1421000);the Research Funds of Happiness Flower ECNU(2020JK2103);the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：英文

中文关键词：acidic medium;gastrointestinal tract;In vivo imaging;near infrared fluorophore

摘要：In vivo imaging in the deep near-infrared(NIR)spectral region,that is,beyond 800 nm,has become popular due to its penetration depth.While imaging of the neutral medium/tissue has been repeatedly showcased,imaging of the high-acidic medium remains challenging partly because of the high-lying HOMO orbital and hence a high pKa of the electron-donating group of the NIR fluorophores.We devised a novel electron-donating group(D6)with which we further synthesized ECJ.ECJ exhibits an absorption wavelength beyond 900 nm and is fluorescent.Its pKa was found to be lower than zero,rendering it suitable for bioimaging of a highly-acidic medium.Its potential for practical applications was showcased in proof-of-concept in vivo imaging with a mouse model.