文献类型：期刊文献

英文题名：Near- Infrared Photoregulated Drug Release in Living Tumor Tissue via Yolk- Shell Upconversion Nanocages

作者：Zhao, Lingzhi[1,2];Peng, Juanjuan[1,2];Huang, Qi[3];Li, Chunyan[1,2];Chen, Min[1,2];Sun, Yun[1,2];Lin, Qiuning[3];Zhu, Linyong[3];Li, Fuyou[1,2]

机构：[1]Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China;[2]Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China;[3]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：24

期号：3

起止页码：363

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20140517240307);WOS:【SCI-EXPANDED(收录号:WOS:000332832500010)】；

基金：This study was financially supported by NSFC (21231004), Shanghai Sci. Tech. Comm. (12JC1401300), MOST of China (2011AA03A407 and 2012CB932403), and the innovative team of Ministry of Education of China (IRT0911).

语种：英文

外文关键词：upconversion; lanthanide nanophosphor; yolk-shell nanoparticles; photoregulated release; tumor therapies

摘要：Phototrigger-controlled drug-release devices (PDDs) can be conveniently manipulated by light to obtain on-demand release patterns, thereby affording an improved therapeutic efficacy. However, no example of the PDDs has been demonstrated beyond the cellular level to date. By loading 7-amino-coumarin derivative caged anticancer drug chlorambucil to yolk-shell structured nanocages possessing upconversion nanophosphors (UCNPs) as moveable core and silica as mesoporous shell, a near-infrared (NIR)-regulated PDD is successfully created. In vitro experiments demonstrate that drug release from the PDD could be triggered by continuous-wave 980 nm light in a controlled pattern. The PDD could be taken up by cancer cells and release the drug to kill cancer cells upon NIR irradiation. Further in vivo studies demonstrate that the PDD can effectively response the NIR stimuli in living tissue. This is the first example of successful NIR-regulated drug release in living animal model. Such achievement resolves the problem of low tissue penetration depth for traditional PDDs by adopting UCNPs as an NIR light switcher, which gives impetus to practical applications.