文献类型：期刊文献

英文题名：Dearomatization of tryptophols via a vanadium-catalyzed asymmetric epoxidation and ring-opening cascade

作者：Han, Long[1,2];Liu, Chuan[2];Zhang, Wei[2];Shi, Xiao-Xin[1];You, Shu-Li[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

年份：2014

卷号：50

期号：10

起止页码：1231

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000329175000019)，CCR-EXPANDED(收录号:WOS:000329175000019)】；

基金：We thank the National Basic Research Program of China (973 Program 2010CB833300) and the National Natural Science Foundation of China (21025209, 21121062, 21272252, 21332009) for generous financial support and Professor Hisashi Yamamoto for helpful discussions.

语种：英文

摘要：An enantioselective epoxidation of tryptophols followed by an intramolecular epoxide opening reaction was realized by chiral vanadium catalysts derived from C-2 symmetric bis-hydroxamic acid (BHA) ligands. 3a-Hydroxyfuroindoline derivatives with up to 89% yield and 90% ee were obtained under mild reaction conditions.