文献类型：期刊文献

英文题名：Rational design of novel near-infrared fluorescent DCM derivatives and their application in bioimaging

作者：Wang, Xiaohang[1,2];Guo, Zhiqian[1,2,4];Zhu, Shiqin[1,2];Liu, Yajing[3];Shi, Ping[3];Tian, He[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Collaborat Innovat Ctr Coal Based Energy i CCE, Inst Fine Chem,Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Collaborat Innovat Ctr Coal Based Energy i CCE, Shanghai Key Lab Funct Mat Chem,Inst Fine Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

年份：2016

卷号：4

期号：27

起止页码：4683

外文期刊名：JOURNAL OF MATERIALS CHEMISTRY B

收录：;EI(收录号：20162902599823);WOS:【SCI-EXPANDED(收录号:WOS:000379491000008)】；

基金：This study was supported by NSFC for Creative Research Groups (21421004), Distinguished Young Scholars (21325625), NSFC/China, the Oriental Scholarship, Scientific Committee of Shanghai (14ZR1409700 and 15XD1501400), Shanghai Pujiang Program (13PJD010), the Fok Ying Tong Education Foundation (142014), the Fundamental Research Funds for the Central Universities (222201313010), and Programme of Introducing Talents of Discipline to Universities (B16017) and the State Key Laboratory of Fine Chemicals (KF1509).

语种：英文

外文关键词：Photobleaching - Fluorescence - Infrared devices - Signal to noise ratio

摘要：The development of innovative strategies for high-performance near-infrared (NIR) fluorescent materials is in urgent demand for bioimaging. By replacing the stronger electron-withdrawing groups or extending the p-conjugated system, novel NIR fluorescent materials of DCM analogues have been developed, along with several striking characteristics: bright NIR fluorescence over 700 nm, large Stokes shift and good photo-stability. It is demonstrated that introducing a stronger electron-withdrawing unit to the acceptor moiety of DCM analogues is a favourably efficient strategy to tune and prolong the emission wavelength into the NIR region with a large Stokes shift. In comparison with the commercial NIR dye ICG, S-DCM-N and S-DCM-P display excellent photostability and low photobleaching. The large Stokes Shift and NIR fluorescence channel of S-DCM-N and S-DCM-P are very favourable for fluorescence labelling with a high signal-to-noise ratio in living species.