文献类型：期刊文献

英文题名：Photo-controlled release of fipronil from a coumarin triggered precursor

作者：Gao, Zhenhong[1];Yuan, Pengtao[1];Wang, Donghui[2];Xu, Zhiping[1];Li, Zhong[1];Shao, Xusheng[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Peking Univ, Coll Life Sci, Beijing 100871, Peoples R China

年份：2017

卷号：27

期号：11

起止页码：2528

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000402023800051)】；

基金：This work was financial supported by National Natural Science Foundation of China (21372079, 21472046), Shanghai Pujiang Program (14PJD012).

语种：英文

外文关键词：Photocaged; Fipronil; Coumarin; Insecticide; Light

摘要：Developing efficient controlled release system of insecticide can facilitate the better use of insecticide. We described here a first example of photo-controlled release of an insecticide by linking fipronil with photoresponsive coumarin covalently. The generated coumarin-fipronil (CF) precursor could undergo cleavage to release free fipronil in the presence of blue light (420 nm) or sunlight. Photophysical studies of CF showed that it exhibited strong fluorescence properties. The CF had no obvious activity against mosquito larvae under dark, but it can be activated by light inside the mosquito larvae. The released Fip from CF by blue light irradiation in vitro retained its activity to armyworm (Mythimna separate) with LC50 value of 24.64 mu mol L-1. This photocaged molecule provided an alternative delivery method for fipronil. (C) 2017 Published by Elsevier Ltd.