文献类型：期刊文献

英文题名：Measurement and correlation of solubility and thermodynamic properties of N-acetyl-l-glutamine in some pure solvents and binary solvents at various temperatures

作者：Chen, Yan[1];Wu, Yanyang[1];Zhang, Xiangyang[2];Chen, Kui[1];Wu, Bin[1];Ji, Lijun[1];Zhu, Jiawen[1]

机构：[1]East China Univ Sci & Technol, Chem Engn Res Ctr, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai, Peoples R China

年份：2019

卷号：206

期号：3

起止页码：355

外文期刊名：CHEMICAL ENGINEERING COMMUNICATIONS

收录：;EI(收录号：20184105924812);WOS:【SCI-EXPANDED(收录号:WOS:000459588400007)】；

基金：The financial support of Shanghai Pujiang Program [Grant No. 16PJD019] and the National Natural Science Foundation of China [Grant No. 21406071] are gratefully acknowledged.

语种：英文

外文关键词：N-acetyl-l-glutamine; Correlation; Solubility; Thermodynamic properties

摘要：The solubility data of N-acetyl-l-glutamine in aqueous solution with different proportions of methanol and ethanol were determined with a static analytical method from 293.15 to 318.15 K. The data were then correlated by five models including the modified Apelblat equation, Van't Hoff equation, local composition model (NRTL model), CNIBS/Redlich-Kister model, and Jouyban-Acree model. The results show that Van't Hoff equation agrees well with the experimental data. When the ratio of methanol or ethanol in aqueous solution is in the range of 0.2-0.4, the solubility of N-acetyl-l-glutamine reaches its maximum. Besides, the melting temperature and fusion enthalpy of N-acetyl-l-glutamine were measured by the differential scanning calorimetry (DSC) and no polymorphism was found in the systems studied. The thermodynamic properties including enthalpy, entropy and Gibbs free energy during dissolution were calculated accordingly in this work.