文献类型：期刊文献

英文题名：Ecotoxicity of bisphenol A to Caenorhabditis elegans by multigenerational exposure and variations of stress response in vivo across generations

作者：Zhou, Dong[1];Yang, Jie[2];Li, Hui[1];Lu, Qiang[1];Liu, Yong-di[1];Lin, Kuang-fei[1]

机构：[1]E China Univ Sci & Technol, Sch Resources & Environm Engn, State Environm Protect Key Lab Environm Risk Asse, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]Shanghai Acad Environm Sci, Res Inst Wastes & Soil Remediat, Shanghai 200233, Peoples R China

年份：2016

卷号：208

起止页码：767

外文期刊名：ENVIRONMENTAL POLLUTION

收录：;EI(收录号：20161202128095);WOS:【SCI-EXPANDED(收录号:WOS:000368306500054)】；

基金：The wild-type nematode strain used in this study was provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). This work was also financially supported by the National Environmental Protection Public Welfare Science and Technology Research Program of China (No. 201309047), National Natural Science Foundation of China (51378208, 41273109), Specialized Research Fund for the Doctoral Program of Higher Education (20110074130002), Program for New Century Excellent Talents in University (NCET-13-0797), Fok Ying Tung Education Foundation (141077), Innovation Program of Shanghai Municipal Education Commission (14ZZ059), Fundamental Research Funds for the Central Universities (222201313008, 222201516015).

语种：英文

外文关键词：Caenorhabditis elegans; Bisphenol A; Multigenerational exposure; Multigenerational toxicity response; Environmental risks

摘要：In order to understand how bisphenol A (BPA) exposure acts on the evolutionary dynamics of populations and changes of stress response across generations, the model animal Caenorhabditis elegans was used to conduct the multigenerational testing. Multiple endpoints at the physiological (growth, reproduction, and locomotion behaviors) and molecular (stress-related gene expressions) levels were examined by multigenerational exposure to low-concentration EPA (0.001-10 mu M) across four generations. The results showed that changes of physiological-level effects across four generations varied in magnitude and direction, depending on the exposure concentrations. C. elegans individuals in the first generation grew smaller, moved slower, and produced less offsprings than the controls by BPA exposure. As for each trait tested, the first generation response could be commonly mirrored in the subsequent generations at the highest concentration of 10 mu M. However, at lower concentrations, response of parental generation was a relatively poor predictor of the effects on progeny, as acclimation or cumulative damage could occur in the subsequent generations. The integrated gene expression profiles visually illustrated that the tested gene expressions at low concentrations (0.001-0.01 mu M) were more obviously changed in both G(1) and G(4) generations, and the G(1) generation showed a much greater degree of increase in stress-related gene expressions than the G(4) generation. The multigenerational toxicity data emphasize the need of considering biological effects over multiple generations to conduct accurate assessment of environmental risks of toxicants on population dynamics. (C) 2015 Elsevier Ltd. All rights reserved.