文献类型：期刊文献

英文题名：Combined Cancer Chemo-Photodynamic and Photothermal Therapy Based on ICG/PDA/TPZ-Loaded Nanoparticles

作者：Huang, Xiaqin[2];Wu, Junru[2];He, Muye[2];Hou, Xinyu[2];Wang, Yan[2];Cai, Xiaoran[2];Xin, Hongliang[4];Gao, Feng[1,2,3];Chen, Yanzuo[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[4]Nanjing Med Univ, Sch Pharm, Dept Pharmaceut, Nanjing 211166, Jiangsu, Peoples R China

年份：2019

卷号：16

期号：5

起止页码：2172

外文期刊名：MOLECULAR PHARMACEUTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000467351300035)】；

基金：This work was supported by National Natural Science Foundation of China (81503021), Natural Science Foundation of Shanghai (17ZR1406600), Science and Technology Commission of Shanghai Municipality (10DZ2220500 and 11DZ2260600).

语种：英文

外文关键词：nanoparticle; chemo-photodynamic therapy; photothermal therapy; polydopamine; indocyanine green; tirapazamine Tumor

摘要：Although photodynamic therapy (PDT) has been an attractive strategy for several cancer treatments in the clinical setting, PDT efficacy is attenuated by consumption of oxygen. To address this photodynamic issue, we adopted a phototherapy-chemotherapy combination strategy based on targeted delivery of the near-infrared photosensitizer indoc-yanine green (ICG), photothermal conversion agent polydop amine (PDA), and tirapazamine (TPZ), a hypoxia-activated prodrug. Under laser irradiation, ICG consumption of oxygen and aggravated hypoxia in tumor sites can activate TPZ to damage DNA. In parallel, ICG produces reactive oxygen species which work in synergy with PDA to enhance phototherapeutic efficiency. Herein, hybrid CaCO3/TPGS nanoparticles delivering ICG, PDA, and TPZ (ICG-PDA-TPZ NPs) were designed for effective and safe cancer therapy. ICG-PDA-TPZ NPs showed significantly improved cellular uptake and accumulation in tumors. Furthermore, we demonstrated that ICG-PDA-TPZ NPs showed intensive photodynamic and photothermal effects in vitro and in vivo, which synergized with TPZ in subcutaneous U87 malignant glioma growth and orthotopic B16F10 tumor inhibition, with negligible side effects. Thus, ICG-PDA-TPZ NPs could be an effective strategy for improvement of PDT.