文献类型：期刊文献

英文题名：An efficient approach to chloro(organophosphine) gold(I) complexes for the synthesis of auranofin

作者：Wang, Junchang[1];Mi, Xuemeng[1];Wang, Jiazhe[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：19

期号：3

起止页码：634

外文期刊名：GREEN CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000395630000007)，CCR-EXPANDED(收录号:WOS:000395630000007)】；

基金：Financial support from the National Thousand Young Talents Program (YC0130518), the Shanghai Pujiang Program (15PJ1401500), the Fundamental Research Funds for the Central Universities (WY1514052), and the Opening Project of State Key Laboratory of Bio-organic and Natural Products Chemistry (Y100-D-1501) is gratefully acknowledged.

语种：英文

摘要：A practical and efficient synthesis of chloro(organophosphine) gold(I) complexes is reported. Employment of 4,4'-dihydroxydiphenyl sulfide as a safe and non-irritating reductant is highlighted for the generation of Au(I)-S intermediates, which could be trapped by mono-and bidentate phosphine ligands to provide organophosphine gold(I) complexes. The utility of the present method is further demonstrated by the synthesis of the antiarthritic drug auranofin.