文献类型：期刊文献

中文题名：甲氧基聚乙二醇-b-聚L-半胱氨酸两亲性嵌段共聚物的合成与表征

英文题名：Synthesis and Characterization of Poly(ethylene glycol)-b-Poly(L-cysteine) Block Copolymer

作者：陈洋[1];肖艳[1]

机构：[1]华东理工大学材料科学与工程学院,上海200237

年份：2016

卷号：29

期号：2

起止页码：188

中文期刊名：功能高分子学报

外文期刊名：Journal of Functional Polymers

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

语种：中文

中文关键词：聚乙二醇单甲醚;巯基;两亲性;嵌段共聚物

外文关键词：poly（ethylene glycol）; thiol group; amphiphilic; block copolymer;

摘要：首先以聚乙二醇单甲醚(mPEG-OH)为单体,采用经典的盖布瑞尔伯胺合成法合成了端氨基聚乙二醇单甲醚(mPEG-NH_2);然后以mPEG-NH_2为引发剂,S-苄基L-半胱氨酸N-羧酸内酸酐(BCys-NCA)为原料,通过N-羧酸内酸酐(NCA)开环聚合反应和液氨/钠处理脱除侧链上的保护基团,合成了两亲性嵌段共聚物甲氧基聚乙二醇-b-聚L-半胱氨酸(mPEG-b-PCys)。采用傅里叶变换红外光谱、核磁共振氢谱对聚合物的结构和组成进行了表征。结果表明:成功制备了侧链具有还原性巯基的两亲性嵌段共聚物mPEG-b-PCys,并且其聚合度可控性良好。
Amine-terminated mPEG（mPEG-NH2） was first synthesized by Gabriel method using mPEG-OH as the monomer.Methoxy poly（ethylene glycol）-b-poly（L-cysteine）（mPEG-b-PCys）amphiphilic block copolymers were further synthesized by ring opening copolymerization of S-benzyl Lcysteine N-carboxyanhydride（BCys-NCA）initiated with the amine terminated mPEG and followed by the removal of the protected groups using liquid NH3/Na.The structures of the polymers were characterized by Nuclear Magnetic Resonance spectroscopy（^1H-NMR）and Fourier Transform Infrared spectroscopy（FT-IR）.Results showed that the amphiphilic block copolymers containing active thiol groups were synthesized successfully,and the degree of polymerization was controllable.