文献类型：期刊文献

英文题名：Synthesis of Highly Functionalized Chiral 3,3′-Disubstituted Oxindoles via an Organocatalytic Enantioselective Michael Addition of Nitroalkanes to Indolylidenecyanoacetates

作者：Liu, Lu[1];Wu, Deyan[1];Zheng, Shu[1];Li, Tengfei[1];Li, Xiangmin[1];Wang, Sinan[1];Li, Jian[1];Li, Hao[1];Wang, Wei[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China;[2]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2012

卷号：14

期号：1

起止页码：134

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000298828500035)，CCR-EXPANDED(收录号:WOS:000298828500035)】；

基金：This research is financially supported by East China University of Science & Technology and the China 111 Project (Grant No. B07023).

语种：英文

摘要：An efficient bifunctional cinchona alkaloid derived thiourea-promoted enantioselective conjugate addition of nitroalkanes to indolylidenecyanoacetates has been developed under neat conditions. The process leads to synthetically interesting densely functionalized 3,3'-disubstituted oxindoles with creation of up to three stereogenic centers.