文献类型：期刊文献

英文题名：Design, Synthesis, Crystal Structures, and Insecticidal Activities of Eight-Membered Azabridge Neonicotinoid Analogues

作者：Xu, Renbo[1];Xia, Rui[1];Luo, Ming[1];Xu, Xiaoyong[1];Cheng, Jiagao[1];Shao, Xusheng[1];Li, Zhong[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2014

卷号：62

期号：2

起止页码：381

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20151500742179);WOS:【SCI-EXPANDED(收录号:WOS:000330018100007)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2010CB126100), the National High Technology Research and Development Program of China (863 Program, 2011AA10A207), and the National Natural Science Foundation of China (21272071). This work was also partly supported by the National Key Technology R&D Program of China (2011BAE06B01) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：oxabridge; azabridge; neonicotinoids; insecticide

摘要：Three series of novel azabridge neonicotinoid analogues were designed and synthesized, which were constructed by starting material A, glutaraldehyde, and primary amine hydrochlorides (aliphatic amines, phenylhydrazines, and anilines). Most of the eight-membered azabridge compounds presented higher insecticidal activities than oxabridged compound B against cowpea aphid (Aphis craccivora) and brown planthopper (Nilaparvata lugens). Compared with imidacloprid, some azabridged compounds exhibited excellent insecticidal activity against brown planthopper. The crystal structures and bioassay indicated that changing bridge atoms from O to N could lead to entirely different conformations, which might be the important influential factor of the bioactivities.